Article
Associations of common genetic variants with age-related changes in fasting and postload glucose: evidence from 18 years of follow-up of the Whitehall II cohort.
Diabetes - 1 May 2011
Jensen Anders C, Barker Adam, Kumari Meena, Brunner Eric J, Kivimäki Mika, Hingorani Aroon D, Wareham Nicholas J, Tabák Adam G, Witte Daniel R, Langenberg Claudia
Abstract excerpt
OBJECTIVE: In the general, nondiabetic population, fasting glucose increases only slightly over time, whereas 2-h postload glucose shows a much steeper age-related rise. The reasons underlying these different age trajectories are unknown. We investigated whether common genetic variants associated with fasting and 2-h glucose contribute to age-related changes of these traits. RESEARCH DESIGN AND METHODS: We...
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