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Article

Metabolic factors and genetic risk mediate familial type 2 diabetes risk in the Framingham Heart Study.

Diabetologia - 1 May 2015

Raghavan Sridharan, Porneala Bianca, McKeown Nicola, Fox Caroline S, Dupuis Josée, Meigs James B

Abstract excerpt

AIMS/HYPOTHESIS: Type 2 diabetes mellitus in parents is a strong determinant of diabetes risk in their offspring. We hypothesise that offspring diabetes risk associated with parental diabetes is mediated by metabolic risk factors. METHODS: We studied initially non-diabetic participants of the Framingham Offspring Study. Metabolic risk was estimated using beta cell corrected insulin response (CIR), HOMA-IR or a...

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Identifiers

PMID: 25619168
DOI: 10.1007/s00125-015-3498-7
PMCID: PMC4393775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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