Article
ERCC1 mutations in UV-sensitive Chinese hamster ovary (CHO) cell lines.
Mutation research - 1 Jun 1998
Hayashi T, Takao M, Tanaka K, Yasui A
Abstract excerpt
In mammalian nucleotide excision repair (NER), the ERCC1 protein is known to act as a complex with ERCC4 (XPF) protein, which is necessary for stability of ERCC1, and this complex introduces an incision on the 5' side of a damaged site in DNA. ERCC1 also binds to XPA protein to make a large prote...
Topics
- Amino Acid Sequence
- Animals
- CHO Cells
- Cricetinae
- DNA Repair
- DNA-Binding Proteins
- Endonucleases
- Female
- Humans
- Molecular Sequence Data
- Mutation
- Proteins
- Radiation Tolerance
- Ultraviolet Rays