Article
Comparative induction of gene mutations and chromosome damage by 1-methoxy-1,3,5-cycloheptatriene (MCHT), 1. Results from a battery of standard tests.
Mutation research - 1 May 1990
Asquith J C, Dewey J, Lee C G, Morris B C, Webber T D
Abstract excerpt
The ability of 1-methoxy-1,3,5-cycloheptatriene (MCHT) to induce gene mutations and chromosome breaks has been examined in a battery of standard assays. MCHT was not mutagenic to 5 strains of Salmonella, with or without S9 fraction. In L5178Y TK+/- mouse lymphoma cells, MCHT induced TK-/- mutants...
Topics
- Animals
- Azaguanine
- Cells, Cultured
- Chromosome Aberrations
- Chromosomes
- Chromosomes, Human
- Cricetinae
- Cycloheptanes
- Drug Resistance
- Genes
- Humans
- Male
- Mice
- Micronucleus Tests
- Mutagenicity Tests
- Mutagens
- Mutation
- Tumor Cells, Cultured