Article
Decemtione (Imidan)-induced single-strand breaks to human DNA, mutations at the hgprt locus of V79 cells, and morphological transformations of embryo cells.
Environmental and molecular mutagenesis - 1 Jan 1992
Slamenová D, Dusinská M, Gábelová A, Bohusová T, Ruppová K
Abstract excerpt
To study the genotoxic activity of Decemtione (Imidan), this substance was subjected to a series of tests. After preliminary cytotoxicity testing, the capacity of Decemtione to damage human DNA was determined by alkaline elution of DNA and DNA unwinding. Both tests gave positive results, suggesti...
Topics
- Animals
- Cell Division
- Cell Line
- Cell Transformation, Neoplastic
- Cricetinae
- DNA Damage
- Humans
- Hypoxanthine Phosphoribosyltransferase
- In Vitro Techniques
- Mesocricetus
- Mutation
- Phosmet