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Induction of gene mutations by 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), an antiviral pyrimidine nucleoside analogue.

Mutation research - 21 Dec 2004

Suter Willi, Plappert-Helbig Ulla, Glowienke Susanne, Poetter-Locher Franziska, Staedtler Frank, Racine Robert, Martus Hans-Joerg

Abstract excerpt

5-(2-chloroethyl)-2'-deoxyuridine (CEDU) had been developed for the treatment of herpes simplex infections. In the Salmonella reverse mutation test, the compound was found to be mutagenic in strains TA1535 and TA102 at very high concentrations (> or =2500 micro g/plate), both with and without S9-mix. The mutagenic potential of CEDU was further investigated in vivo and in vitro. It did not induce DNA repair in rat...

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Identifiers

PMID: 15542107
DOI: 10.1016/j.mrfmmm.2004.08.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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