Tracking a tuberculosis outbreak over 21 years: strain-specific single-nucleotide polymorphism typing combined with targeted whole-genome sequencing.

doi:10.1093/infdis/jiu601

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Article

Tracking a tuberculosis outbreak over 21 years: strain-specific single-nucleotide polymorphism typing combined with targeted whole-genome sequencing.

The Journal of infectious diseases - 15 Apr 2015

Stucki David, Ballif Marie, Bodmer Thomas, Coscolla Mireia, Maurer Anne-Marie, Droz Sara, Butz Christa, Borrell Sonia, Längle Christel, Feldmann Julia, Furrer Hansjakob, Mordasini Carlo, Helbling Peter, Rieder Hans L, Egger Matthias, Gagneux Sébastien, Fenner Lukas

Abstract excerpt

BACKGROUND: Whole-genome sequencing (WGS) is increasingly used in molecular-epidemiological investigations of bacterial pathogens, despite cost- and time-intensive analyses. We combined strain-specific single-nucleotide polymorphism (SNP) typing and targeted WGS to investigate a tuberculosis cluster spanning 21 years in Bern, Switzerland. METHODS: On the basis of genome sequences of 3 historical outbreak...

Topics

Adult
Aged
Bacterial Typing Techniques
DNA, Bacterial
Disease Outbreaks
Female
Genome, Bacterial
Genotype
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Epidemiology

Mycobacterium tuberculosis

Polymorphism, Single Nucleotide

Retrospective Studies

Sequence Analysis, DNA

Switzerland

Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 25362193
DOI: 10.1093/infdis/jiu601
PMCID: PMC4447836

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