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Article

Conserved regional 3' grouping of rare codons in the coding sequence of ocular prosecretory mitogen lacritin.

Investigative ophthalmology & visual science - 19 Mar 2013

McKown Robert L, Raab Ronald W, Kachelries Patricia, Caldwell Sara, Laurie Gordon W

Abstract excerpt

PURPOSE: Lacritin is a prosecretory mitogen in tears and, although a tear protein, it promotes basal tearing and lacrimal gland secretion. Since scale up is relevant to its potential use in the treatment of dry eye, we explored various mutagenic strategies to alter the stability, solubility, and translational efficiency of nascent lacritin, and discovered 3' clustering of rare human codons. METHODS: Site-directed...

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Identifiers

PMID: 23422824
DOI: 10.1167/iovs.12-10740
PMCID: PMC3604909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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