Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Codon-Directed Determination of the Biological Causes of Sequence Variants in Therapeutic Proteins.

Analytical chemistry - 5 Dec 2017

Jiang Tao, Song Hangtian, Slaney Thomas R, Wu Wei, Langsdorf Erik, Gupta Gargi, Ludwig Richard, Tao Li, McVey Duncan, Das Tapan K

Abstract excerpt

Recombinant monoclonal antibodies (mAbs) manufactured from immortalized mammalian cell lines are becoming increasingly important as therapies. Ensuring the quality of expressed proteins is critical when developing manufacturing processes. Protein sequence variants (PSVs) are a type of product-related variant in which errors in the protein sequence are present. Detecting PSVs and determining their origins, either...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Antibodies, Monoclonal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CHO Cells

Share to Chromatography, Liquid

Share to Cricetulus

Share to Protein Biosynthesis

Share to Tandem Mass Spectrometry

Source

Identifiers

PMID: 29086552
DOI: 10.1021/acs.analchem.7b02914

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Codon-Directed Determination of the Biological Causes of Sequence Variants in Therapeutic Proteins.PMID 29086552Read ↗

An optimized approach to the rapid assessment and detection of sequence variants in recombinant protein products.Semantic proximity Read ↗

Eliminating tyrosine sequence variants in CHO cell lines producing recombinant monoclonal antibodiesSemantic proximity Read ↗

A general evidence-based sequence variant control limit for recombinant therapeutic protein developmentSemantic proximity Read ↗

Identifying low-level sequence variants via next generation sequencing to aid stable CHO cell line screening.Semantic proximity Read ↗

Early identification of unusually clustered mutations and root causes in therapeutic antibody development.Semantic proximity Read ↗

Phenotypic mutations contribute to protein diversity and shape protein evolution.Semantic proximity Read ↗

A systemic approach to identifying sequence frameworks that decrease mAb production in a transient Chinese hamster ovary cell expression system.Semantic proximity Read ↗

Mutation Detection in an Antibody-Producing Chinese Hamster Ovary Cell Line by Targeted RNA Sequencing.Semantic proximity Read ↗

Optimizing Bispecific Antibody Expression via Multi-Omics Analysis and Vector RedesignSemantic proximity Read ↗

Mechanisms of unintended amino acid sequence changes in recombinant monoclonal antibodies expressed in Chinese Hamster Ovary (CHO) cellsSemantic proximity Read ↗

Mass spectrometry-based multi-attribute method for mutation analysis in the early development of therapeutic proteins.Semantic proximity Read ↗

Protein mistranslation: friend or foe?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.