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Structural, functional, and immunogenicity implications of F9 gene recoding

12 Apr 2022

Abstract excerpt

Hemophilia B is a blood clotting disorder caused by deficient activity of coagulation factor IX (FIX). Multiple recombinant FIX proteins are currently approved to treat hemophilia B, and several gene therapy products are currently being developed. Codon optimization is a frequently used technique in the pharmaceutical industry to improve recombinant protein expression by recoding a coding sequence using multiple...

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PMID: 35413099
DOI: 10.1182/bloodadvances.2022007094

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