Article

Integrative Computational and Experimental Analysis of Curly Su Mutations in Drosophila melanogaster

2025-09-17

Abstract excerpt

The Curly Su (dMPO) protein, a homolog of the human myeloperoxidase (hMPO), is critical for wing development in Drosophila melanogaster. Like human peroxidases, dMPO is involved in various cellular and physiological processes, producing significant quantities of reactive oxygen species that contribute to both development and immunity in the fruit fly. Given the significant sequence and structural similarities betw...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 383d2a20-be15-582b-8da2-e9b956c4ddf0
DOI: 10.1101/2025.09.15.676221

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative Computational and Experimental Analysis of Curly Su Mutations in Drosophila melanogasterDOI 10.1101/2025.09.15.676221Read

Curly Encodes Dual Oxidase, Which Acts with Heme Peroxidase Curly Su to Shape the Adult Drosophila Wing.Semantic proximity Read

Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database.Semantic proximity Read

Assigning functionality to cysteines by base editing of cancer dependency genesSemantic proximity Read

A Computational Approach: The Functional Effects of Thyroid Peroxidase Variants in Thyroid Cancer and Genetic Disorders.Semantic proximity Read

A compact, portable degron tool derived from the 3′UTR of <i>MTCH2</i> for tunable degradation of proteinsSemantic proximity Read

Perturbed heme binding is responsible for the blistering phenotype associated with mutations in the Caenorhabditis elegans dual oxidase 1 (DUOX1) peroxidase domain.Semantic proximity Read

The essential requirement of an animal heme peroxidase protein during the wing maturation process in Drosophila.Semantic proximity Read

Double synonymous mutations in exon 9 of the Cullin3 gene restore exon inclusion by abolishing hnRNPs inhibition.Semantic proximity Read

Ten novel mutations in the molybdenum cofactor genes MOCS1 and MOCS2 and in vitro characterization of a MOCS2 mutation that abolishes the binding ability of molybdopterin synthase.Semantic proximity Read

Landscapes of missense variant impact for human superoxide dismutase 1Semantic proximity Read

JiangShi: a widely distributed Mucin-like protein essential for Drosophila developmentSemantic proximity Read

LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundanceSemantic proximity Read