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Article

Immunohistochemical detection of mutations in the epidermal growth factor receptor gene in lung adenocarcinomas using mutation-specific antibodies.

Diagnostic pathology - 18 Feb 2013

Xiong Yan, Bai Yun, Leong Nufatt, Laughlin Todd S, Rothberg Paul G, Xu Haodong, Nong Lin, Zhao Jing, Dong Ying, Li Ting

Abstract excerpt

BACKGROUND: The recent development of antibodies specific for the major hotspot mutations in the epidermal growth factor receptor (EGFR), L858R and E746_A750del, may provide an opportunity to use immunohistochemistry (IHC) as a screening test for EGFR gene mutations. This study was designed to optimize the IHC protocol and the criteria for interpretation of the results using DNA sequencing as the gold-standard....

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Identifiers

PMID: 23419122
DOI: 10.1186/1746-1596-8-27
PMCID: PMC3635899

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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