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Article

Including total EGFR staining in scoring improves EGFR mutations detection by mutation-specific antibodies and EGFR TKIs response prediction.

PloS one - 1 Jan 2011

Wu Shang-Gin, Chang Yih-Leong, Lin Jou-Wei, Wu Chen-Tu, Chen Hsuan-Yu, Tsai Meng-Feng, Lee Yung-Chie, Yu Chong-Jen, Shih Jin-Yuan

Abstract excerpt

Epidermal growth factor receptor (EGFR) is a novel target for therapy in subsets of non-small cell lung cancer, especially adenocarcinoma. Tumors with EGFR mutations showed good response to EGFR tyrosine kinase inhibitors (TKIs). We aimed to identify the discriminating capacity of immunohistochemical (IHC) scoring to detect L858R and E746-A750 deletion mutation in lung adenocarcinoma patients and predict EGFR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21858063
DOI: 10.1371/journal.pone.0023303
PMCID: PMC3153495

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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