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Article

Absence of Nrf2 or its selective overexpression in neurons and muscle does not affect survival in ALS-linked mutant hSOD1 mouse models.

PloS one - 1 Jan 2013

Vargas Marcelo R, Burton Neal C, Kutzke Jennifer, Gan Li, Johnson Delinda A, Schäfer Matthias, Werner Sabine, Johnson Jeffrey A

Abstract excerpt

The nuclear factor erythroid 2-related factor 2 (Nrf2) governs the expression of antioxidant and phase II detoxifying enzymes. Nrf2 activation can prevent or reduce cellular damage associated with several types of injury in many different tissues and organs. Dominant mutations in Cu/Zn-superoxide dismutase (SOD1) cause familial forms of amyotrophic lateral sclerosis (ALS), a fatal disorder characterized by the...

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Source

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Identifiers

PMID: 23418589
DOI: 10.1371/journal.pone.0056625
PMCID: PMC3572065

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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