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Article

Activation of the Nrf2-ARE pathway in muscle and spinal cord during ALS-like pathology in mice expressing mutant SOD1.

Experimental neurology - 1 Sept 2007

Kraft Andrew D, Resch Jon M, Johnson Delinda A, Johnson Jeffrey A

Abstract excerpt

Oxidative stress plays a key role in the neuronal loss exhibited in amyotrophic lateral sclerosis (ALS), an event precipitating irreversible muscle atrophy. By crossing ALS mouse models (SOD(G93A) and SOD(H46RH48Q)) with an antioxidant response element (ARE) reporter mouse, we identified activation characteristics of the ARE system throughout the timecourse of motor neuron disease. Surprisingly, the earliest and...

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Source

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Identifiers

PMID: 17631292
DOI: 10.1016/j.expneurol.2007.05.026
PMCID: PMC2062571

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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