Article

Absence of subcerebral projection neurons delays disease onset and extends survival in a mouse model of ALS

2019-11-21

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease of adulthood that affects voluntary motricity and rapidly leads to full paralysis and death. ALS arises from the combined degeneration of motoneurons in the spinal cord and brain stem, responsible for muscle denervation, and corticospinal projection neurons (CSN), responsible for emergence of the upper motor neuron syndrome. Recent studies ca...

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Literature Corpus work: 418cac91-8434-527d-937c-6019ecc203f1
DOI: 10.1101/849935

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