Article
QTL-based association analyses reveal novel genes influencing pleiotropy of metabolic syndrome (MetS).
Obesity (Silver Spring, Md.) - 1 Oct 2013
Zhang Y, Kent J W, Olivier M, Ali O, Broeckel U, Abdou R M, Dyer T D, Comuzzie A, Curran J E, Carless M A, Rainwater D L, Göring H H H, Blangero J, Kissebah A H
Abstract excerpt
OBJECTIVE: Metabolic Syndrome (MetS) is a phenotype cluster predisposing to type 2 diabetes and cardiovascular disease. We conducted a study to elucidate the genetic basis underlying linkage signals for multiple representative traits of MetS that we had previously identified at two significant QTLs on chromosomes 3q27 and 17p12. DESIGN AND METHODS: We performed QTL-specific genomic and transcriptomic analyses in...
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