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Reproductive Ageing: Metabolic contribution to age-related chromosome missegregation in mammalian oocytes

7 May 2024

Abstract excerpt

In brief: Chromosome missegregation and declining energy metabolism are considered to be unrelated features of oocyte ageing that contribute to poor reproductive outcomes. Given the bioenergetic cost of chromosome segregation, we propose here that altered energy metabolism during ageing may be an underlying cause of age-related chromosome missegregation and aneuploidy. Abstract: Advanced reproductive age in women...

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Identifiers

PMID: 38718822
DOI: 10.1530/rep-23-0510

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