Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutants of listeriolysin O for enhanced liposomal delivery of macromolecules.

Journal of biotechnology - 15 Apr 2013

Walls Zachary F, Goodell Stefanie, Andrews Chasity D, Mathis Jonathan, Lee Kyung-Dall

Abstract excerpt

Delivery of macromolecules into the cytosolic space of eukaryotic cells is a pressing challenge in biopharmaceutics. Macromolecules are often encapsulated into liposomes for protection and improved distribution, but the their size often induces endocytosis of the vehicle at the target site, leading to degradation of the cargo. Listeriolysin O is a key virulence factor of Listeria monocytogenes that forms pores in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Toxins
Share to Cluster Analysis
Share to Drug Delivery Systems

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heat-Shock Proteins

Share to Hemolysin Proteins

Share to Liposomes

Share to Mutagenesis, Site-Directed

Share to Protein Conformation

Source

Identifiers

PMID: 23416330
DOI: 10.1016/j.jbiotec.2013.01.029

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutants of listeriolysin O for enhanced liposomal delivery of macromolecules.PMID 23416330Read ↗

Site‐directed mutagenesis, isolation and purification of listeria monocytogenes listeriolysin o and its immunogenicitySemantic proximity Read ↗

Listeriolysin O: a genuine cytolysin optimized for an intracellular parasite.Semantic proximity Read ↗

Development of a single-gene, signature-tag-based approach in combination with alanine mutagenesis to identify listeriolysin O residues critical for the in vivo survival of Listeria monocytogenes.Semantic proximity Read ↗

The relationship between Listeria infections and host immune responses: Listeriolysin O as a potential targetSemantic proximity Read ↗

A PEST-like sequence in listeriolysin O essential for Listeria monocytogenes pathogenicity.Semantic proximity Read ↗

How Virulence of <em>Listeria monocytogenes </em>Can Be Harnessed to Develop an Immunotherapeutic AgentSemantic proximity Read ↗

Regulated translation of listeriolysin O controls virulence of Listeria monocytogenes.Semantic proximity Read ↗

Protective immunity induced by a LLO-deficient Listeria monocytogenes.Semantic proximity Read ↗

Modification of the signal sequence cleavage site of listeriolysin O does not affect protein secretion but impairs the virulence of Listeria monocytogenes.Semantic proximity Read ↗

19F NMR studies provide insights into lipid membrane interactions of listeriolysin O, a pore forming toxin from Listeria monocytogenes.Semantic proximity Read ↗

Crystal structure of listeriolysin O reveals molecular details of oligomerization and pore formation.Semantic proximity Read ↗

Prospective uses of recombinant Lactococcus lactis expressing both listeriolysin O and mutated internalin A from Listeria monocytogenes as a tool for DNA vaccination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.