Article
19F NMR studies provide insights into lipid membrane interactions of listeriolysin O, a pore forming toxin from Listeria monocytogenes.
Scientific reports - 2 May 2018
Kozorog Mirijam, Sani Marc-Antoine, Lenarčič Živković Martina, Ilc Gregor, Hodnik Vesna, Separovic Frances, Plavec Janez, Anderluh Gregor
Abstract excerpt
Listeria monocytogenes is a mammalian pathogen that causes gastroenteritis, miscarriages and infections of the central nervous system in immunocompromised individuals. Its main virulence factor is listeriolysin O (LLO), a pore-forming cholesterol-dependent cytolysin (CDC), which enables bacterial escape from the phagolysosome and contributes to bacterial pathogenicity. Details of cholesterol (Chol) recognition...
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