Article
Predicting longevity in C. elegans: fertility, mobility and gene expression.
Mechanisms of ageing and development - 1 Jan 2000
Cypser James R, Wu Deqing, Park Sang-Kyu, Ishii Takamasa, Tedesco Patricia M, Mendenhall Alexander R, Johnson Thomas E
Abstract excerpt
Expression level of an hsp-16.2::gfp transgene is a predictor of longevity in Caenorhabditis elegans. Here we examine fertility, movement and longevity, comparing high-expressing ("bright") and low-expressing ("dim") animals. There was no differential fertility between bright and dim individuals, suggesting that dim worms were not excessively frail. Worms with high hsp-16.2::gfp expression had improved mobility,...
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