Article
Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jul 2001
Walker G A, White T M, McColl G, Jenkins N L, Babich S, Candido E P, Johnson T E, Lithgow G J
Abstract excerpt
We present evidence for elevated levels of heat shock protein 16 (HSP16) in an intrinsically thermotolerant, long-lived strain of Caenorhabditis elegans during and after heat stress. Mutation of the age-1 gene, encoding a phosphatidylinositol 3-kinase catalytic subunit, results in both extended life span (Age) and increased intrinsic thermotolerance (Itt) in adult hermaphrodites. We subjected age-synchronous...
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