Article
Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts.
Molecular neurodegeneration - 15 Feb 2013
Vardarajan Badri, Vergote David, Tissir Fadel, Logue Mark, Yang Jing, Daude Nathalie, Ando Kunie, Rogaeva Ekaterina, Lee Joseph, Cheng Rong, Brion Jean-Pierre, Ghani Mahdi, Shi Beipei, Baldwin Clinton T, Kar Satyabrata, Mayeux Richard, Fraser Paul, Goffinet André M, George-Hyslop Peter St, Farrer Lindsay A, Westaway David
Abstract excerpt
BACKGROUND: P73 belongs to the p53 family of cell survival regulators with the corresponding locus Trp73 producing the N-terminally distinct isoforms, TAp73 and DeltaNp73. Recently, two studies have implicated the murine Trp73 in the modulation in phospho-tau accumulation in aged wild type mice and in young mice modeling Alzheimer's disease (AD) suggesting that Trp73, particularly the DeltaNp73 isoform, links the...
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