Article
p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease.
Neuron - 11 Sept 2008
Wetzel Monica K, Naska Sibel, Laliberté Christine L, Rymar Vladimir V, Fujitani Masashi, Biernaskie Jeffrey A, Cole Christy J, Lerch Jason P, Spring Shoshana, Wang S-H, Frankland Paul W, Henkelman R Mark, Josselyn Sheena A, Sadikot Abbas F, Miller Freda D, Kaplan David R
Abstract excerpt
The genetic mechanisms that regulate neurodegeneration are only poorly understood. We show that the loss of one allele of the p53 family member, p73, makes mice susceptible to neurodegeneration as a consequence of aging or Alzheimer's disease (AD). Behavioral analyses demonstrated that old, but not young, p73+/- mice displayed reduced motor and cognitive function, CNS atrophy, and neuronal degeneration....
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