Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Actin with tumor-related mutation is antimorphic in Drosophila muscle: two distinct modes of myofibrillar disruption by antimorphic actins.

Journal of biochemistry - 1 Mar 1990

Sakai Y, Okamoto H, Mogami K, Yamada T, Hotta Y

Abstract excerpt

A mutant beta-actin with an amino acid substitution from Gly-245 to Asp has been shown to be related to tumorigenic transformation of a human fibroblast cell line (Leavitt, J. et al. (1987) Mol. Cell. Biol. 7, 2467-2476). To examine the effects of this mutation, we artificially introduced the same amino acid change into the Act88F actin gene of Drosophila melanogaster. The gene (Act88FGD245) was inserted in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Drosophila
Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microscopy, Electron

Share to Muscles

Share to Mutation

Share to Phenotype

Share to Transformation, Genetic

Source

Identifiers

PMID: 2341381
DOI: 10.1093/oxfordjournals.jbchem.a123074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Actin with tumor-related mutation is antimorphic in Drosophila muscle: two distinct modes of myofibrillar disruption by antimorphic actins.PMID 2341381Read ↗

Differential epitope tagging of actin in transformed Drosophila produces distinct effects on myofibril assembly and function of the indirect flight muscle.Semantic proximity Read ↗

Characterisation of missense mutations in the Act88F gene of Drosophila melanogaster.Semantic proximity Read ↗

Isolation of 88F actin mutants of Drosophila melanogaster and possible alterations in the mutant actin structures.Semantic proximity Read ↗

Heat shock gene activation by mutant actin is independent of myofibril degeneration in Drosophila muscle.Semantic proximity Read ↗

Drosophila ACT88F indirect flight muscle-specific actin is not N-terminally acetylated: a mutation in N-terminal processing affects actin function.Semantic proximity Read ↗

Expression and function of the Drosophila ACT88F actin isoform is not restricted to the indirect flight muscles.Semantic proximity Read ↗

Drosophila indirect flight muscle specific Act88F actin mutants as a model system for studying congenital myopathies of the human ACTA1 skeletal muscle actin gene.Semantic proximity Read ↗

Functional and ultrastructural effects of a missense mutation in the indirect flight muscle-specific actin gene of Drosophila melanogaster.Semantic proximity Read ↗

Drosophila actin mutants and the study of myofibrillar assembly and function.Semantic proximity Read ↗

Insights into the effects of disease-causing mutations in human actins.Semantic proximity Read ↗

Dominant negative mutant actins identified in flightless Drosophila can be classified into three classes.Semantic proximity Read ↗

Mutant profilin suppresses mutant actin-dependent mitochondrial phenotype in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.