Actin with tumor-related mutation is antimorphic in Drosophila muscle: two distinct modes of myofibrillar disruption by antimorphic actins.

doi:10.1093/oxfordjournals.jbchem.a123074

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Article

Actin with tumor-related mutation is antimorphic in Drosophila muscle: two distinct modes of myofibrillar disruption by antimorphic actins.

Journal of biochemistry - 1 Mar 1990

Sakai Y, Okamoto H, Mogami K, Yamada T, Hotta Y

Abstract excerpt

A mutant beta-actin with an amino acid substitution from Gly-245 to Asp has been shown to be related to tumorigenic transformation of a human fibroblast cell line (Leavitt, J. et al. (1987) Mol. Cell. Biol. 7, 2467-2476). To examine the effects of this mutation, we artificially introduced the sam...

Topics

Actins
Animals
Drosophila
Electrophoresis, Polyacrylamide Gel
Flight, Animal
Microscopy, Electron
Muscle Proteins
Muscles
Mutation
Myofibrils
Phenotype
Transformation, Genetic

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