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Article

Functional and ultrastructural effects of a missense mutation in the indirect flight muscle-specific actin gene of Drosophila melanogaster.

Journal of molecular biology - 20 Dec 1991

Sparrow J, Reedy M, Ball E, Kyrtatas V, Molloy J, Durston J, Hennessey E, White D

Abstract excerpt

A single-site mutation of the flight-muscle-specific actin gene of Drosophila melanogaster causes a substitution of glutamic acid 93 by lysine in all the actin encoded in the indirect flight muscle (IFM). In these Act88FE93K mutants, myofibrillar bundles of thick and thin filaments are present but lack Z-discs and all sarcomeric repeats. Dense filament bundles, which are probably aberrant Z-discs, are seen in...

Topics

Actins
Amino Acid Sequence
Animals
Cloning, Molecular
Drosophila melanogaster
Flight, Animal
Glutamates
Glutamic Acid
Lysine
Microscopy, Electron
Muscle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle Relaxation

Muscles

Mutation

Myofibrils

Peptide Mapping

Source

Identifiers

PMID: 1684824
DOI: 10.1016/0022-2836(91)90588-w

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1684824-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Functional and ultrastructural effects of a missense mutation in the indirect flight muscle-specific actin gene of Drosophila melanogaster.PMID 1684824Read ↗

Drosophila indirect flight muscle specific Act88F actin mutants as a model system for studying congenital myopathies of the human ACTA1 skeletal muscle actin gene.Semantic proximity Read ↗

Differential epitope tagging of actin in transformed Drosophila produces distinct effects on myofibril assembly and function of the indirect flight muscle.Semantic proximity Read ↗

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