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Article

Dominant negative mutant actins identified in flightless Drosophila can be classified into three classes.

The Journal of biological chemistry - 12 Feb 2010

Noguchi Taro Q P, Gomibuchi Yuki, Murakami Kenji, Ueno Hironori, Hirose Keiko, Wakabayashi Takeyuki, Uyeda Taro Q P

Abstract excerpt

Strongly dominant negative mutant actins, identified by An and Mogami (An, H. S., and Mogami, K. (1996) J. Mol. Biol. 260, 492-505), in the indirect flight muscle of Drosophila impaired its flight, even when three copies of the wild-type gene were present. Understanding how these strongly dominant negative mutant actins disrupt the function of wild-type actin would provide useful information about the molecular...

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PMID: 19933578
DOI: 10.1074/jbc.M109.059881
PMCID: PMC2836038

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