Isolation of 88F actin mutants of Drosophila melanogaster and possible alterations in the mutant actin structures.

doi:10.1006/jmbi.1996.0417

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Article

Isolation of 88F actin mutants of Drosophila melanogaster and possible alterations in the mutant actin structures.

Journal of molecular biology - 26 Jul 1996

An H S, Mogami K

Abstract excerpt

The 88F actin (act88F) gene of Drosophila, melanogaster encodes an actin isoform that is expressed exclusively in the indirect flight muscle. In order to isolate a large number of act88F mutants, an efficient screening method was used to obtain dominant flightless mutants. Genetic analyses revealed that 25 mutations were located near or at the act88F locus. From each mutant strain, the DNA fragments including the...

Topics

Actins
Animals
Base Sequence
Drosophila melanogaster
Electrophoresis, Gel, Two-Dimensional
Female
Male
Models, Molecular
Molecular Sequence Data
Muscle Fibers, Skeletal
Mutation
Myofibrils
Phenotype
Polymerase Chain Reaction
Protein Conformation
Sequence Analysis, DNA
Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 8759316
DOI: 10.1006/jmbi.1996.0417

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