Heat shock gene activation by mutant actin is independent of myofibril degeneration in Drosophila muscle.

doi:10.1093/oxfordjournals.jbchem.a123438

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Article

Heat shock gene activation by mutant actin is independent of myofibril degeneration in Drosophila muscle.

Journal of biochemistry - 1 May 1991

Sakai Y, Okamoto H, Mogami K, Matsuo H, Hotta Y

Abstract excerpt

Artificially mutagenized Drosophila Act88F actin genes with triple and double mutations were expressed in the indirect flight muscles of transgenic flies. The triple mutant actin, GD245T (Gly-36----Glu, Glu-83----Asp, and Gly-245----Asp), induced heat shock protein (hsp) synthesis without affecti...

Topics

Actins
Animals
Drosophila
Gene Expression Regulation
Heat-Shock Proteins
Muscles
Mutation
Myofibrils
Phenotype
Transcriptional Activation

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