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Article

Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2013

Liang Chao-Fan, Liu Jacky Tc, Wang Yu, Xu Aimin, Vanhoutte Paul M

Abstract excerpt

OBJECTIVE: To analyze the role of toll-like receptor 4 in modulating metabolism and endothelial function. APPROACH AND RESULTS: Type 2 diabetic mice with mutated toll-like receptor 4 (DWM) were protected from hyperglycemia and hypertension, despite an increased body weight. Isometric tension was measured in arterial rings with endothelium. Relaxations to acetylcholine were blunted in aortae and mesenteric...

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Source

Identifiers

PMID: 23413427
DOI: 10.1161/ATVBAHA.112.301087

Genes

NOX1
NOX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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