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Article

Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17.

British journal of clinical pharmacology - 1 Mar 2010

Li-Wan-Po Alain, Girard Thierry, Farndon Peter, Cooley Candy, Lithgow James

Abstract excerpt

AIMS: Cytochrome P450 2C19 metabolizes many important drugs. In 2006, a variant allele (CYP2C19*17) associated with increased activity was discovered, but its likely clinical significance is controversial. Investigators disagree about the phenotype to be assigned to the two CYP2C19*17 genotypes. The aim of this study was to provide a critical summary, helpful to prescribers. METHODS: We searched MEDLINE for...

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Alleles
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2C19
Genetic Variation
Pharmaceutical Preparations

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Pharmacogenetics

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PMID: 20233192
DOI: 10.1111/j.1365-2125.2009.03578.x
PMCID: PMC2829691

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