Article
Impact of CYP2C19 Gene Variants on Long-Term Treatment with Atorvastatin in Patients with Acute Coronary Syndromes.
International journal of molecular sciences - 15 May 2024
Čereškevičius Darius, Zabiela Vytautas, Aldujeli Ali, Lesauskaitė Vaiva, Zubielienė Kristina, Raškevičius Vytautas, Čiapienė Ieva, Žaliaduonytė Diana, Giedraitienė Agnė, Žvikas Vaidotas, Jakštas Valdas, Skipskis Vilius, Dobilienė Olivija, Šakalytė Gintarė, Tatarūnas Vacis
Abstract excerpt
The effectiveness of lipid-lowering therapies may be insufficient in high-risk cardiovascular patients and depends on the genetic variability of drug-metabolizing enzymes. Customizing statin therapy, including treatment with atorvastatin, may improve clinical outcomes. Currently, there is a lack of guidelines allowing the prediction of the therapeutic efficacy of lipid-lowering statin therapy. This study aimed to...
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