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Article

Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice.

Circulation - 26 Jul 2005

Song Yanli, Jones John E, Beppu Hideyuki, Keaney John F, Loscalzo Joseph, Zhang Ying-Yi

Abstract excerpt

BACKGROUND: Bone morphogenetic protein receptor-2 (BMPR2)-heterozygous, mutant (BMPR2(+/-)) mice have a genetic trait similar to that of certain patients with idiopathic pulmonary arterial hypertension (IPAH). To understand the role of BMPR2 in the development of IPAH, we examined the phenotype of BMPR2(+/-) mice and their response to inflammatory stress. METHODS AND RESULTS: BMPR2(+/-) mice were found to have...

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Source

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Identifiers

PMID: 16027259
DOI: 10.1161/CIRCULATIONAHA.104.492488
PMCID: PMC1472405

Genes

BMPR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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