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Article

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

8 Aug 2019

Abstract excerpt

The most frequently mutated protein in human cancer is p53, a transcription factor (TF) that regulates myriad genes instrumental in diverse cellular outcomes including growth arrest and cell death. Cell context-dependent p53 modulation is critical for this life-or-death balance, yet remains incompletely understood. Here we identify sequence signatures enriched in genomic p53-binding sites modulated by the...

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PMID: 31395738
DOI: 10.1073/pnas.1909393116

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