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Article

A crucial role of ROCK for alleviation of senescence-associated phenotype.

Experimental gerontology - 1 Jun 2018

Park Joon Tae, Kang Hyun Tae, Park Chi Hyun, Lee Young-Sam, Cho Kyung A, Park Sang Chul

Abstract excerpt

In our previous study, we uncovered a novel mechanism in which amelioration of Hutchinson-Gilford progeria syndrome (HGPS) phenotype is mediated by mitochondrial functional recovery upon rho-associated protein kinase (ROCK) inhibition. However, it remains elusive whether this mechanism is also applied to the amelioration of normal aging cells. In this study, we used Y-27632 and fasudil as effective ROCK...

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PMID: 29474864
DOI: 10.1016/j.exger.2018.02.012

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