Article

Acetylcholine signaling in the medial prefrontal cortex mediates the ability to learn an active avoidance response following learned helplessness training

2023-09-23

Abstract excerpt

Increased brain levels of acetylcholine (ACh) are observed in subsets of patients with depression and increasing ACh levels chronically can precipitate stress-related behaviors in humans and animals. Conversely, optimal ACh levels are required for cognition and memory. We hypothesize that ACh signaling is important for encoding both appetitive and stress-relevant memories, but that excessive increases in ACh resul...

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Literature Corpus work: 24930efe-20bb-5c55-afcb-c0ec6aaf10e2
DOI: 10.1101/2023.09.23.559126

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