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Article

Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents.

Chemistry & biology - 21 Feb 2013

Wang Hao, Gill Charles J, Lee Sang H, Mann Paul, Zuck Paul, Meredith Timothy C, Murgolo Nicholas, She Xinwei, Kales Susan, Liang Lianzhu, Liu Jenny, Wu Jin, Santa Maria John, Su Jing, Pan Jianping, Hailey Judy, Mcguinness Debra, Tan Christopher M, Flattery Amy, Walker Suzanne, Black Todd, Roemer Terry

Abstract excerpt

Innovative strategies are needed to combat drug resistance associated with methicillin-resistant Staphylococcus aureus (MRSA). Here, we investigate the potential of wall teichoic acid (WTA) biosynthesis inhibitors as combination agents to restore β-lactam efficacy against MRSA. Performing a whole-cell pathway-based screen, we identified a series of WTA inhibitors (WTAIs) targeting the WTA transporter protein,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23438756
DOI: 10.1016/j.chembiol.2012.11.013
PMCID: PMC3762323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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