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Article

Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis.

Nature structural & molecular biology - 1 Jun 2020

Zhang Bing, Liu Xue, Lambert Elisabeth, Mas Guillaume, Hiller Sebastian, Veening Jan-Willem, Perez Camilo

Abstract excerpt

Lipoteichoic acids (LTAs) are essential cell-wall components in Gram-positive bacteria, including the human pathogen Staphylococcus aureus, contributing to cell adhesion, cell division and antibiotic resistance. Genetic evidence has suggested that LtaA is the flippase that mediates the translocation of the lipid-linked disaccharide that anchors LTA to the cell membrane, a rate-limiting step in S. aureus LTA...

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Identifiers

PMID: 32367070
DOI: 10.1038/s41594-020-0425-5
PMCID: PMC7611249

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