TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.

doi:10.1126/scitranslmed.aad7364

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Article

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.

Science translational medicine - 9 Mar 2016

Lee Sang Ho, Wang Hao, Labroli Marc, Koseoglu Sandra, Zuck Paul, Mayhood Todd, Gill Charles, Mann Paul, Sher Xinwei, Ha Sookhee, Yang Shu-Wei, Mandal Mihir, Yang Christine, Liang Lianzhu, Tan Zheng, Tawa Paul, Hou Yan, Kuvelkar Reshma, DeVito Kristine, Wen Xiujuan, Xiao Jing, Batchlett Michelle, Balibar Carl J, Liu Jenny, Xiao Jianying, Murgolo Nicholas, Garlisi Charles G, Sheth Payal R, Flattery Amy, Su Jing, Tan Christopher, Roemer Terry

Abstract excerpt

The widespread emergence of methicillin-resistant Staphylococcus aureus (MRSA) has dramatically eroded the efficacy of current β-lactam antibiotics and created an urgent need for new treatment options. We report an S. aureus phenotypic screening strategy involving chemical suppression of the growth inhibitory consequences of depleting late-stage wall teichoic acid biosynthesis. This enabled us to identify...

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PMID: 26962156
DOI: 10.1126/scitranslmed.aad7364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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