Discovery of a Small Molecule that Blocks Wall Teichoic Acid Biosynthesis in <i>Staphylococcus aureus</i>

Abstract excerpt

Both Gram-positive and Gram-negative bacteria contain bactoprenol-dependent biosynthetic pathways expressing non-essential cell surface polysaccharides that function as virulence factors. Although these polymers are not required for bacterial viability in vitro, genes in many of the biosynthetic pathways are conditionally essential: they cannot be deleted except in strains incapable of initiating polymer...

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