Article
Alternations of central insulin-like growth factor-1 sensitivity in APP/PS1 transgenic mice and neuronal models.
Journal of neuroscience research - 1 May 2013
Zhang Bing, Tang Xi Can, Zhang Hai Yan
Abstract excerpt
Although many post-mortem studies have found evidence of central insulin resistance in Alzheimer's disease (AD) patients, results on changes of central insulin-like growth factor-1 (IGF-1) signaling in the pathological process of AD remain controversial. In the present study, we observed the acti...
Topics
- Age Factors
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Brain
- CHO Cells
- Cricetinae
- Culture Media, Conditioned
- Disease Models, Animal
- Disks Large Homolog 4 Protein
- Gene Expression Regulation
- Guanylate Kinases
- Humans
- In Vitro Techniques
- Insulin-Like Growth Factor I
- Male
- Membrane Proteins