Article
Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?
Neurobiology of aging - 1 Nov 2006
Carro Eva, Trejo Jose Luis, Spuch Carlos, Bohl Delphine, Heard Jean Michel, Torres-Aleman Ignacio
Abstract excerpt
The possibility that perturbed insulin/insulin-like growth factor I (IGF-I) signalling is involved in development of late-onset forms of Alzheimer's disease (AD) is gaining increasing attention. We recently reported that circulating IGF-I participates in brain amyloid beta (Abeta) clearance by mo...
Topics
- Aging
- Alzheimer Disease
- Animals
- Blotting, Western
- Cell Culture Techniques
- Choroid Plexus
- Epithelial Cells
- Glycogen Synthase Kinase 3
- Green Fluorescent Proteins
- Humans
- Insulin-Like Growth Factor I
- Maze Learning
- Mice
- Mice, Inbred C57BL