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Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?

Neurobiology of aging - 1 Nov 2006

Carro Eva, Trejo Jose Luis, Spuch Carlos, Bohl Delphine, Heard Jean Michel, Torres-Aleman Ignacio

Abstract excerpt

The possibility that perturbed insulin/insulin-like growth factor I (IGF-I) signalling is involved in development of late-onset forms of Alzheimer's disease (AD) is gaining increasing attention. We recently reported that circulating IGF-I participates in brain amyloid beta (Abeta) clearance by modulating choroid plexus function. We now present evidence that blockade of the IGF-I receptor in the choroid plexus...

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PMID: 16274856
DOI: 10.1016/j.neurobiolaging.2005.09.039

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