Article
Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's disease.
Age (Dordrecht, Netherlands) - 1 Feb 2013
Stöhr Oliver, Schilbach Katharina, Moll Lorna, Hettich Moritz M, Freude Susanna, Wunderlich F Thomas, Ernst Marianne, Zemva Johanna, Brüning Jens C, Krone Wilhelm, Udelhoven Michael, Schubert Markus
Abstract excerpt
In brains from patients with Alzheimer's disease (AD), expression of insulin receptor (IR), insulin-like growth factor-1 receptor (IGF-1R), and insulin receptor substrate proteins is downregulated. A key step in the pathogenesis of AD is the accumulation of amyloid precursor protein (APP) cleavage products, β-amyloid (Aβ)(1-42) and Aβ(1-40). Recently, we and others have shown that central IGF-1 resistance reduces...
Topics
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Disease Models, Animal
- Enzyme-Linked Immunosorbent Assay
- Genotype
- Humans
- Immunoblotting