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Article

Computationally designed peptide inhibitors of the ubiquitin E3 ligase SCF(Fbx4).

Chembiochem : a European journal of chemical biology - 4 Mar 2013

Lee Junglim, Sammond Deanne W, Fiorini Zeno, Saludes Jonel P, Resch Michael G, Hao Bing, Wang Wei, Yin Hang, Liu Xuedong

Abstract excerpt

A structure-based computational approach was used to rationally design peptide inhibitors that can target an E3 ligase (SCF(Fbx4) )-substrate (TRF1) interface and subsequent ubiquitylation. Characterization of the inhibitors demonstrates that our sequence-optimization protocol results in an incre...

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Identifiers

PMID: 23401343
DOI: 10.1002/cbic.201200777
PMCID: PMC4028150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23401343-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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