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Article

A new thiopurine s-methyltransferase haplotype associated with intolerance to azathioprine.

Journal of clinical pharmacology - 1 Jan 2013

Colleoni Lara, Kapetis Dimos, Maggi Lorenzo, Camera Giorgia, Canioni Eleonora, Cavalcante Paola, Kerlero de Rosbo Nicole, Baggi Fulvio, Antozzi Carlo, Confalonieri Paolo, Mantegazza Renato, Bernasconi Pia

Abstract excerpt

The authors have analyzed single nucleotide polymorphisms in the thiopurine S-methyltransferase (TPMT) gene in the context of efficacy and toxicity of azathioprine (AZA) to determine possible genotype-phenotype correlations between TPMT allelic variants and response to AZA treatment in 76 Italian patients with myasthenia gravis. They confirm known intronic and exonic TPMT polymorphisms that do not correlate with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23400745
DOI: 10.1177/0091270011435989

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A new thiopurine s-methyltransferase haplotype associated with intolerance to azathioprine.PMID 23400745Read ↗

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