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Article

Identification of a novel thiopurine S-methyltransferase allele (TPMT*37).

Pharmacogenetics and genomics - 1 Jun 2014

Roberts Rebecca L, Wallace Mary C, Drake Jill M, Stamp Lisa K

Abstract excerpt

Thiopurine S-methyltransferase (TPMT) is a key enzyme in the methylation of the thiopurine drugs azathioprine and 6-mercaptopurine. TPMT is subject to genetic polymorphism that results in a trimodal distribution of enzyme activity. All poor methylators (PMs) and 30-60% of intermediate methylators...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24710034
DOI: 10.1097/FPC.0000000000000049

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24710034-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Identification of a novel thiopurine S-methyltransferase allele (TPMT*37).PMID 24710034Read ↗

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Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods.Semantic proximity Read ↗

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