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Article

Theoretical underpinning of the single-molecule-dilution (SMD) method of direct haplotype resolution.

American journal of human genetics - 1 Jun 1990

Stephens J C, Rogers J, Ruano G

Abstract excerpt

In a recent paper we have shown that DNA haplotypes of multiply heterozygous individuals can be resolved directly by polymerase-chain-reaction (PCR) amplification of a single molecule of genomic template. Our method (the single-molecule-dilution [SMD] method) relies on the stochastic separation of maternal and paternal alleles at high dilution. The stochasticity of separation and the potential for DNA shearing...

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Identifiers

PMID: 2339707
PMCID: PMC1683843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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