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Article

Theoretical underpinning of the single-molecule-dilution (SMD) method of direct haplotype resolution.

American journal of human genetics - 1 Jun 1990

Stephens J C, Rogers J, Ruano G

Abstract excerpt

In a recent paper we have shown that DNA haplotypes of multiply heterozygous individuals can be resolved directly by polymerase-chain-reaction (PCR) amplification of a single molecule of genomic template. Our method (the single-molecule-dilution [SMD] method) relies on the stochastic separation o...

Topics

Alleles
DNA
Haplotypes
Heterozygote
Humans
Nucleic Acid Amplification Techniques
Polymerase Chain Reaction
Probability

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2339707
PMCID: PMC1683843

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2339707-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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