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Article

Haplotype of multiple polymorphisms resolved by enzymatic amplification of single DNA molecules.

1 Aug 1990

Abstract excerpt

We have developed a reliable method for the direct resolution of haplotypes or linkage phase from individuals who are multiply heterozygous in a given genomic region. The method is based on single-molecule dilution (SMD) of genomic template and amplification via biphasic polymerase chain reaction (booster PCR). We have verified the feasibility of the SMD method for a highly polymorphic region within the...

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Identifiers

PMID: 1974719
DOI: 10.1073/pnas.87.16.6296

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Source receipt: pubmed, retrieved 7 Sept 2026.

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