Article
Remote control of neuronal activity with a light-gated glutamate receptor.
Neuron - 24 May 2007
Szobota Stephanie, Gorostiza Pau, Del Bene Filippo, Wyart Claire, Fortin Doris L, Kolstad Kathleen D, Tulyathan Orapim, Volgraf Matthew, Numano Rika, Aaron Holly L, Scott Ethan K, Kramer Richard H, Flannery John, Baier Herwig, Trauner Dirk, Isacoff Ehud Y
Abstract excerpt
The ability to stimulate select neurons in isolated tissue and in living animals is important for investigating their role in circuits and behavior. We show that the engineered light-gated ionotropic glutamate receptor (LiGluR), when introduced into neurons, enables remote control of their activity. Trains of action potentials are optimally evoked and extinguished by 380 nm and 500 nm light, respectively, while...
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