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Article

Opsin 5 mediates violet light-accelerated wound healing in mammalian corneas

22 Jul 2025

Abstract excerpt

The cornea is the transparent tissue at the ocular surface that generates most of the refractive power of the eye. Due to its exposed location, the cornea is uniquely in danger of injury. Rapid and efficient healing is required for high-acuity vision. Here, we show that epithelial corneal wounding induces Opn5, an opsin G-protein-coupled receptor (GPCR) sensitive to ultraviolet/violet light, at the cornea's...

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PMID: 40700017
DOI: 10.1016/j.celrep.2025.116045

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